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drugbank:ahfsCode 12:12.00
drugbank:ahfsCode 12:12.12
drugbank:ahfsCode 92:01.00*
drugbank:atcCode R01AA03
drugbank:atcCode R01AB05
drugbank:atcCode R01BA02
drugbank:atcCode R03CA02
drugbank:atcCode S01FB02
drugbank:casRegistryNumber <http://bio2rdf.org/cas:299-42-3>
drugbank:chebiId <http://bio2rdf.org/chebi:15407>
drugbank:chemicalFormula C10H15NO
drugbank:chemicalIupacName (1R,2S)-2-methylamino-1-phenylpropan-1-ol
drugbank:creationDate 2007-07-06 19:56:02 UTC
drugbank:description An alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. [PubChem]
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/capsuleOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/liquidIntramuscular>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/liquidIntravenous>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/powderOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/solutionIntramuscular>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/tabletOral>
drugbank:dpdDrugIdNumber 00038121
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/adrenergicAgents>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/centralNervousSystemStimulants>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/sympathomimetics>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/vasoconstrictorAgents>
drugbank:drugIdNumberPage <http://205.193.93.51/dpdonline/searchRequest.do?din=00038121>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/approved>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/smallMolecule>
drugbank:experimentalLogpHydrophobicity 1.13 [AVDEEF,A (1997)]
drugbank:experimentalWaterSolubility 63.6 mg/mL at 30 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
drugbank:genericName Ephedrine
drugbank:inchiIdentifier InChI=1/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
drugbank:inchiKey KWGRBVOPPLSCSI-WPRPVWTQBH
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drugbank:keggCompoundId <http://bio2rdf.org/cpd:C01575>
drugbank:keggDrugId <http://bio2rdf.org/kegg:D00124>
rdfs:label Ephedrine
drugbank:limsDrugId 1364
drugbank:massSpecFile 1
drugbank:mechanismOfAction Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic α-receptors and β-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action.
drugbank:meltingPoint 34 oC
drugbank:molecularWeightAverage 165.2322
drugbank:molecularWeightMono 165.1154
foaf:page <http://dbpedia.org/page/Ephedrine>
foaf:page <http://en.wikipedia.org/wiki/Ephedrine>
foaf:page <http://www.drugbank.ca/drugs/DB01364>
drugbank:pharmgkbId PA449466
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/162>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/1643>
drugbank:predictedLogpHydrophobicity 1.00
drugbank:predictedLogs -1.30
drugbank:predictedWaterSolubility 8.26e+00 mg/mL
drugbank:primaryAccessionNo DB01364
drugbank:pubchemCompoundId 9294
drugbank:pubchemSubstanceId 10517637
drugbank:rxlistLink <http://www.rxlist.com/cgi/generic/ephedrine.htm>
owl:sameAs <http://data.linkedct.org/resource/intervention/4979>
owl:sameAs <http://dbpedia.org/resource/Ephedrine>
drugbank:smilesStringCanonical CNC(C)C(O)C1=CC=CC=C1
drugbank:smilesStringIsomeric CN[C@@H](C)[C@H](O)C1=CC=CC=C1
drugbank:state Solid
drugbank:structure 1
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/474>
rdf:type drugbank:drugs
rdf:type vocabClass:Offer
drugbank:updateDate 2008-08-26 16:20:39 UTC