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drugbank:absorption Rapidly absorbed from the gastrointestinal tract
drugbank:affectedOrganism Parasitic nematodes and other roundworms
drugbank:ahfsCode 08:08.00
drugbank:ahfsCode 92:02.00*
drugbank:atcCode P02CB01
drugbank:atcCode R03DA09
drugbank:biotransformation About 25% is metabolized in the liver. Piperazine is nitrosated to form N -mononitrosopiperazine (MNPz) in gastric juice, which is then metabolized to N-nitroso-3-hydroxypyrrolidine (NHPYR).
drugbank:brandMixture Canoids Cap (Aloin + Areca Catechu + Arecoline HBr + Benzocaine + Piperazine Citrate + Santonin)
drugbank:brandMixture Dyrex T F (Phenothiazine + Piperazine + Trichlorfon)
drugbank:brandMixture Feloids Tab (Aloin + Areca Catechu + Arecoline HBr + Benzocaine + Piperazine Citrate + Santonin)
drugbank:brandMixture Multi Wormer for Cats (Dichlorophene + Piperazine (Piperazine Citrate))
drugbank:brandMixture Multi Wormer for Dogs (Dichlorophene + Piperazine (Piperazine Citrate))
drugbank:brandMixture Ripercol Horse Wormer (Piperazine (Piperazine Hydrochloride) + Tetramisole HCl)
drugbank:brandName Anatensol
drugbank:brandName Antepan
drugbank:brandName Antepar
drugbank:brandName Antiren
drugbank:brandName Asca-Trol No. 3
drugbank:brandName Bryrel
drugbank:brandName Dapotum
drugbank:brandName Dispermine
drugbank:brandName Entacyl
drugbank:brandName Eraverm
drugbank:brandName Lumbrical
drugbank:brandName Lyogen
drugbank:brandName Moditen
drugbank:brandName Multifuge
drugbank:brandName Omca
drugbank:brandName Pacinol
drugbank:brandName Permitil
drugbank:brandName Piperazidine
drugbank:brandName Pipersol
drugbank:brandName Siqualone
drugbank:brandName Tasnon
drugbank:brandName Tensofin
drugbank:brandName Upixon
drugbank:brandName Uvilon
drugbank:brandName Valamina
drugbank:brandName Vermex
drugbank:brandName Vermidol
drugbank:brandName Vermizine
drugbank:brandName Worm-A-Ton
drugbank:brandName Worm-away
drugbank:brandName Wurmirazin
drugbank:casRegistryNumber <http://bio2rdf.org/cas:110-85-0>
drugbank:chebiId <http://bio2rdf.org/chebi:28568>
drugbank:chemicalFormula C4H10N2
drugbank:chemicalIupacName piperazine
drugbank:contraindicationInsert <http://129.128.185.122/drugbank2/drugs/DB00592/inserts/1405/full>
drugbank:creationDate 2005-06-13 13:24:05 UTC
drugbank:description Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/liquidOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/solution/DropsOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/syrupOral>
drugbank:dpdDrugIdNumber 00097128
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/anthelmintics>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/antinematodalAgents>
drugbank:drugIdNumberPage <http://205.193.93.51/dpdonline/searchRequest.do?din=00097128>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/approved>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/smallMolecule>
drugbank:experimentalLogpHydrophobicity -0.8
drugbank:experimentalLogs 1.07 [ADME Research, USCD]
drugbank:experimentalWaterSolubility 150 mg/mL
drugbank:foodInteraction Take without regard to meals.
drugbank:genericName Piperazine
drugbank:hetId 169
drugbank:inchiIdentifier InChI=1/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2
drugbank:inchiKey GLUUGHFHXGJENI-UHFFFAOYAS
drugbank:indication Used as alternative treatment for ascariasis caused by <i>Ascaris lumbricoides</i> (roundworm) and enterobiasis (oxyuriasis) caused by <i>Enterobius vermicularis</i> (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
drugbank:interactionInsert <http://129.128.185.122/drugbank2/drugs/DB00592/inserts/2403/full>
drugbank:keggCompoundId <http://bio2rdf.org/cpd:C07973>
drugbank:keggDrugId <http://bio2rdf.org/kegg:D00807>
rdfs:label Piperazine
drugbank:limsDrugId 592
drugbank:massSpecFile 1
drugbank:mechanismOfAction Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
drugbank:meltingPoint 106 oC
drugbank:molecularWeightAverage 86.1356
drugbank:molecularWeightMono 86.0844
drugbank:msdsFiles /drugs/592/safety_sheets/901
foaf:page <http://dbpedia.org/page/Piperazine>
foaf:page <http://en.wikipedia.org/wiki/Piperazine>
foaf:page <http://www.drugbank.ca/drugs/DB00592>
drugbank:pharmacology Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
drugbank:pharmgkbId PA450977
drugbank:pkaIsoelectricPoint 9.73
drugbank:predictedLogpHydrophobicity -1.15
drugbank:predictedLogs 0.63
drugbank:predictedWaterSolubility 3.71e+02 mg/mL
drugbank:primaryAccessionNo DB00592
drugbank:proteinBinding 60-70%
drugbank:pubchemCompoundId 4837
drugbank:pubchemSubstanceId 7847872
drugbank:reference
owl:sameAs <http://dbpedia.org/resource/Piperazine>
drugbank:secondaryAccessionNumber aprd00225
drugbank:smilesStringCanonical C1CNCCN1
drugbank:smilesStringIsomeric C1CNCCN1
drugbank:state Solid
drugbank:structure 1
drugbank:synonym Diethylenediamine
drugbank:synonym Diethyleneimine
drugbank:synonym Diketopiperazine
drugbank:synonym Glycine anhydride
drugbank:synonym Hexahydropyrazine
drugbank:synonym Piperazin
drugbank:synonym Piperazin [Germany]
drugbank:synonym Piperazine Citrate
drugbank:synonym Piperazine hexahydrate
drugbank:synonym Piperazine hydrate
drugbank:synonym Prolixin Decanoate
drugbank:synonym fluphenazine dihydrochloride
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/348>
drugbank:toxicity LD<sub>50</sub> = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.
rdf:type drugbank:drugs
rdf:type vocabClass:Offer
drugbank:updateDate 2008-08-26 15:18:25 UTC