[RDF data]
Home | All drugs
PropertyValue
drugbank:absorption Absorption is rapid, absolute bioavailability (compared to intravenous administration) is about 30-40% at doses of 20-40 mg.
drugbank:affectedOrganism Humans and other mammals
drugbank:ahfsCode 56:28.36
drugbank:atcCode A02BC01
drugbank:atcCode A02BC05
drugbank:biotransformation Hepatic.
drugbank:brandName Antra
drugbank:brandName Audazol
drugbank:brandName Aulcer
drugbank:brandName Belmazol
drugbank:brandName Ceprandal
drugbank:brandName Danlox
drugbank:brandName Demeprazol
drugbank:brandName Desec
drugbank:brandName Dizprazol
drugbank:brandName Dudencer
drugbank:brandName Elgam
drugbank:brandName Emeproton
drugbank:brandName Epirazole
drugbank:brandName Erbolin
drugbank:brandName Exter
drugbank:brandName Gasec
drugbank:brandName Gastrimut
drugbank:brandName Gastroloc
drugbank:brandName Gibancer
drugbank:brandName Indurgan
drugbank:brandName Inhibitron
drugbank:brandName Inhipump
drugbank:brandName Lensor
drugbank:brandName Logastric
drugbank:brandName Lomac
drugbank:brandName Losec
drugbank:brandName Mepral
drugbank:brandName Miol
drugbank:brandName Miracid
drugbank:brandName Mopral
drugbank:brandName Morecon
drugbank:brandName Nilsec
drugbank:brandName Nopramin
drugbank:brandName Ocid
drugbank:brandName Olexin
drugbank:brandName Omapren
drugbank:brandName Omebeta 20
drugbank:brandName Omed
drugbank:brandName Omegast
drugbank:brandName Omepral
drugbank:brandName Omeprazon
drugbank:brandName Omeprol
drugbank:brandName Omesek
drugbank:brandName Omezol
drugbank:brandName Omezolan
drugbank:brandName Omid
drugbank:brandName Omisec
drugbank:brandName Omizac
drugbank:brandName Ompanyt
drugbank:brandName Ortanol
drugbank:brandedDrug <http://wifo5-04.informatik.uni-mannheim.de/dailymed/resource/drugs/1365>
drugbank:brandedDrug <http://wifo5-04.informatik.uni-mannheim.de/dailymed/resource/drugs/2220>
drugbank:brandedDrug <http://wifo5-04.informatik.uni-mannheim.de/dailymed/resource/drugs/2499>
drugbank:casRegistryNumber <http://bio2rdf.org/cas:73590-58-6>
drugbank:chemicalFormula C17H19N3O3S
drugbank:chemicalIupacName 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
drugbank:contraindicationInsert <http://129.128.185.122/drugbank2/drugs/DB00338/inserts/1221/full>
drugbank:creationDate 2005-06-13 13:24:05 UTC
drugbank:description A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and zollinger-ellison syndrome. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-exchanging ATPase) in the proton pump of gastric parietal cells. [PubChem]
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/capsuleDelayedReleaseOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/capsuleOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/tabletDelayedReleaseOral>
drugbank:dpdDrugIdNumber 02260867
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/anti-ulcerAgents>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/enzymeInhibitors>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/proton-pumpInhibitors>
drugbank:drugIdNumberPage <http://205.193.93.51/dpdonline/searchRequest.do?din=02260867>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/approved>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/investigational>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/smallMolecule>
drugbank:enzyme <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/enzymes/1>
drugbank:experimentalLogpHydrophobicity 0.6
drugbank:experimentalWaterSolubility 82.3 mg/L
drugbank:fdaLabelFiles 2002-07-01 /drugs/338/fda_labels/608 2003-06-01 /drugs/338/fda_labels/312
drugbank:foodInteraction Avoid alcohol.
drugbank:foodInteraction Take 30-60 minutes before meals.
drugbank:genericName Omeprazole
drugbank:halfLife 0.5-1 hour
drugbank:inchiIdentifier InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/f/h20H
drugbank:inchiKey SUBDBMMJDZJVOS-UYBDAZJACN
drugbank:indication For the treatment of gastroesophageal reflux disease.
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00091>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00224>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00252>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00280>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00404>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00467>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00475>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00532>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00563>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00582>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00628>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00683>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00690>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00754>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00801>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00829>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB00897>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01026>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01068>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01072>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01166>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01167>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01215>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01254>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01320>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01323>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01587>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01588>
is drugbank:interactionDrug1 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00338_DB01589>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00091_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00224_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00252_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00404_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00475_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00563_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00628_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00683_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00690_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00829_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB00897_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01026_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01068_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01072_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01166_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01167_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01215_DB00338>
is drugbank:interactionDrug2 of <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drug_interactions/DB01320_DB00338>
drugbank:interactionInsert <http://129.128.185.122/drugbank2/drugs/DB00338/inserts/2226/full>
drugbank:keggCompoundId <http://bio2rdf.org/cpd:C07324>
drugbank:keggDrugId <http://bio2rdf.org/kegg:D00455>
rdfs:label Omeprazole
drugbank:limsDrugId 338
drugbank:massSpecFile 0
drugbank:mechanismOfAction Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H<sup>+</sup>/K<sup>+</sup>-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity.
drugbank:meltingPoint 156 oC
drugbank:molecularWeightAverage 345.416
drugbank:molecularWeightMono 345.1147
drugbank:msdsFiles /drugs/338/safety_sheets/735
foaf:page <http://dbpedia.org/page/Omeprazole>
foaf:page <http://en.wikipedia.org/wiki/Omeprazole>
foaf:page <http://www.drugbank.ca/drugs/DB00338>
drugbank:patientInformationInsert http://129.128.185.122/drugbank2/drugs/DB00338/inserts/350/full
drugbank:pdrhealthLink http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pri1350.shtml
drugbank:pharmacology Omeprazole is a compound that inhibits gastric acid secretion and is indicated in the treatment of gastroesophageal reflux disease (GERD), the healing of erosive esophagitis, and <i>H. pylori</i> eradication to reduce the risk of duodenal ulcer recurrence. Omeprazole belongs to a new class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2 histamine antagonistic properties, but that suppress gastric acid secretion by specific inhibition of the H<sup>+</sup>/K<sup>+</sup> ATPase enzyme system at the secretory surface of the gastric parietal cell. Because this enzyme system is regarded as the acid (proton) pump within the gastric mucosa, omeprazole has been characterized as a gastric acid-pump inhibitor, in that it blocks the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus.
drugbank:predictedLogpHydrophobicity 1.91
drugbank:predictedLogs -2.98
drugbank:predictedWaterSolubility 3.59e-01 mg/mL
drugbank:primaryAccessionNo DB00338
drugbank:proteinBinding 95%
drugbank:pubchemCompoundId 4594
drugbank:pubchemSubstanceId 189970
drugbank:reference
drugbank:rxlistLink <http://www.rxlist.com/cgi/generic/omepra.htm>
owl:sameAs <http://data.linkedct.org/resource/intervention/10264>
owl:sameAs <http://data.linkedct.org/resource/intervention/23635>
owl:sameAs <http://data.linkedct.org/resource/intervention/25738>
owl:sameAs <http://data.linkedct.org/resource/intervention/27563>
owl:sameAs <http://data.linkedct.org/resource/intervention/35888>
owl:sameAs <http://data.linkedct.org/resource/intervention/44400>
owl:sameAs <http://data.linkedct.org/resource/intervention/58973>
owl:sameAs <http://dbpedia.org/resource/Omeprazole>
owl:sameAs <http://www.dbpedia.org/resource/Omeprazole>
drugbank:secondaryAccessionNumber aprd00446
drugbank:smilesStringCanonical COC1=CC2=C(C=C1)N=C(N2)S(=O)CC1=NC=C(C)C(OC)=C1C
drugbank:smilesStringIsomeric COC1=CC2=C(C=C1)N=C(N2)[S@@](=O)CC1=NC=C(C)C(OC)=C1C
drugbank:state Solid
drugbank:structure 1
drugbank:synonym OMEP
drugbank:synonym OMP
drugbank:synonym OMZ
drugbank:synonym Omeprazol [INN-Spanish]
drugbank:synonym Omeprazole magnesium
drugbank:synonym Omeprazolum [INN-Latin]
drugbank:synonym omeprazole
drugbank:synthesisReference U. K. Junggren, S. E. Sjostrand, U.S. Pat. 4,255,431 (1979)
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/385>
drugbank:toxicity Symptoms of overdose include confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, and dry mouth.
rdf:type drugbank:drugs
rdf:type vocabClass:Offer
drugbank:updateDate 2008-08-26 14:11:18 UTC

The server is configured to display only a limited number of values (limit per property bridge: 50).



Metadata