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drugbank:absorption Rapid and complete, 50%
drugbank:affectedOrganism Humans and other mammals
drugbank:ahfsCode 24:24.00
drugbank:atcCode C07AB02
drugbank:atcCode C07AB52
drugbank:biotransformation Primarily hepatic
drugbank:brandName Beloc
drugbank:brandName Betaloc
drugbank:brandName Lopresor
drugbank:brandName Lopresoretic
drugbank:brandName Lopressor
drugbank:brandName Lopressor HCT
drugbank:brandName Metroprolol
drugbank:brandName Prelis
drugbank:brandName Selo-Zok
drugbank:brandName Seloken
drugbank:brandName Selopral
drugbank:brandName Toprol
drugbank:brandName Toprol-XL
drugbank:casRegistryNumber <http://bio2rdf.org/cas:37350-58-6>
drugbank:chebiId <http://bio2rdf.org/chebi:6904>
drugbank:chemicalFormula C15H25NO3
drugbank:chemicalIupacName 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
drugbank:contraindicationInsert <http://129.128.185.122/drugbank2/drugs/DB00264/inserts/788/full>
drugbank:creationDate 2005-06-13 13:24:05 UTC
drugbank:description A selective adrenergic beta-1-blocking agent with no stimulatory action. It&#39;s binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias. [PubChem]
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drugbank:dpdDrugIdNumber 02253518
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drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/investigational>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/smallMolecule>
drugbank:enzyme <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/enzymes/1>
drugbank:experimentalCaco2Permeability -4.59 [ADME Research, USCD]
drugbank:experimentalLogpHydrophobicity 1.6
drugbank:experimentalWaterSolubility 16.9 mg/mL
drugbank:fdaLabelFiles 2000-07-01 /drugs/264/fda_labels/831
drugbank:foodInteraction Avoid alcohol.
drugbank:foodInteraction Avoid natural licorice.
drugbank:foodInteraction Take with food.
drugbank:genericName Metoprolol
drugbank:halfLife 3-7 hours
drugbank:inchiIdentifier InChI=1/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
drugbank:inchiKey IUBSYMUCCVWXPE-UHFFFAOYAN
drugbank:indication For the treatment of hypertension and angina pectoris.
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drugbank:keggCompoundId <http://bio2rdf.org/cpd:C07202>
drugbank:keggDrugId <http://bio2rdf.org/kegg:D02358>
rdfs:label Metoprolol
drugbank:limsDrugId 264
drugbank:massSpecFile 0
drugbank:mechanismOfAction Like betaxolol and atenolol, metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
drugbank:meltingPoint 120 oC (tartarate salt)
drugbank:molecularWeightAverage 267.3639
drugbank:molecularWeightMono 267.1834
drugbank:msdsFiles /drugs/264/safety_sheets/1172
foaf:page <http://dbpedia.org/page/Metoprolol>
foaf:page <http://en.wikipedia.org/wiki/Metoprolol>
foaf:page <http://www.drugbank.ca/drugs/DB00264>
drugbank:patientInformationInsert http://129.128.185.122/drugbank2/drugs/DB00264/inserts/61/full
drugbank:pharmacology Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/1984>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/261>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3734>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/989>
drugbank:predictedLogpHydrophobicity 1.80
drugbank:predictedLogs -2.82
drugbank:predictedWaterSolubility 4.02e-01 mg/mL
drugbank:primaryAccessionNo DB00264
drugbank:proteinBinding 12%
drugbank:pubchemCompoundId 4171
drugbank:pubchemSubstanceId 205122
drugbank:reference
drugbank:rxlistLink <http://www.rxlist.com/cgi/generic/metopxl.htm>
owl:sameAs <http://data.linkedct.org/resource/intervention/18799>
owl:sameAs <http://data.linkedct.org/resource/intervention/25963>
owl:sameAs <http://data.linkedct.org/resource/intervention/40559>
owl:sameAs <http://data.linkedct.org/resource/intervention/42963>
owl:sameAs <http://data.linkedct.org/resource/intervention/55086>
owl:sameAs <http://data.linkedct.org/resource/intervention/9213>
owl:sameAs <http://dbpedia.org/resource/Metoprolol>
owl:sameAs <http://wifo5-04.informatik.uni-mannheim.de/sider/resource/drugs/4171>
owl:sameAs <http://www.dbpedia.org/resource/Metoprolol>
drugbank:secondaryAccessionNumber aprd00208
drugbank:smilesStringCanonical COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
drugbank:smilesStringIsomeric COCCC1=CC=C(OC[C@H](O)CNC(C)C)C=C1
drugbank:state Solid
drugbank:structure 1
drugbank:synonym Metoprolol Tartrate
drugbank:synonym Metoprolol succinate
drugbank:synthesisReference A. E. Brandstorm et al., U.S. Pat. 3,873,600 (1975)
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/193>
drugbank:toxicity LD<sub>50</sub>=5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD<sub>50</sub>=2090 mg/kg (orally in mice)
rdf:type drugbank:drugs
rdf:type vocabClass:Offer
drugbank:updateDate 2008-08-26 15:54:13 UTC

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