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drugbank:absorption Readily absorbed from the normal gastrointestinal tract
drugbank:affectedOrganism Humans and other mammals
drugbank:ahfsCode 88:04.00
drugbank:atcCode A11CA01
drugbank:atcCode V04CB01
drugbank:biotransformation Hepatic. Retinol is conjugated with glucuronic acid; the B-glucuronide undergoes enterohepatic circulation and oxidation to retinol and retinoic acid. Retinoic acid undergoes decarboxylation and conjugation with glucuronic acid.
drugbank:brandMixture Acetabolan-Ii Vitamin and Mineral Supplement (Magnesium (Magnesium Hvp Chelate) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Zinc (Zinc Hvp Chelate))
drugbank:brandMixture Aureo S-700 Beef Cattle Vitamin Premix Crumbles (Chlortetracycline Hydrochloride + Sulfamethazine + Vitamin a (Vitamin a Acetate, Vitamin a Palmitate) + Vitamin D3 (Cholecalciferol))
drugbank:brandMixture Avengers Vitamin and Mineral Supplement (Selenium (Sodium Selenite) + Vitamin C (Ascorbic Acid) + Vitamin E (Alpha Tocopherol) + Zinc (Zinc Gluconate))
drugbank:brandMixture Children's Chewable Multi-Vitamin Complete with Minerals (Biotin + Calcium (Calcium Phosphate (Dibasic)) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron (
drugbank:brandMixture Childrens Chew Multi Vitamin Tab (Folic Acid + Nicotinamide + Vitamin a + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitamin D + Vitamin E)
drugbank:brandMixture Dry Super Vitamin a Plus D - Cap (Vitamin a (Retinol Palmitate) + Vitamin D3)
drugbank:brandMixture Food Nutrition Inc. Men's Vitamin and Mineral Supplement (Copper (Copper Gluconate) + Selenium (Selenium Amino Acid Chelate) + Vitamin a (Vitamin a Palmitate) + Vitamin C + Vitamin E (D-Alpha Tocopher
drugbank:brandMixture Formula O-Care Vitamin and Mineral Supplement (Biotin + Calcium (Calcium Carbonate, Hydroxyapatite) + Copper (Copper Hvp Chelate) + Folic Acid + Magnesium (Magnesium Oxide) + Manganese (Manganese Hvp
drugbank:brandMixture Forty Plus Vitamin Supplement (Biotin + Choline Bitartrate + D-Pantothenic Acid + Inositol + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Cyanocoba
drugbank:brandMixture Gnc Vitamin a and D From Fish Liver Oil (Vitamin a (Fish Liver Oil) + Vitamin D (Fish Liver Oil))
drugbank:brandMixture Infants' Multiple Vitamin Drops (Vitamin a (Vitamin a Palmitate) + Vitamin C (Ascorbic Acid, Sodium Ascorbate) + Vitamin D (Cholecalciferol))
drugbank:brandMixture Insur-All Vitamin Supplement (Biotin + Choline Bitartrate + D-Pantothenic Acid + Inositol + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Cyanocobal
drugbank:brandMixture Liquid Vitamin a-D-E 5t (Vitamin a Propionate + Vitamin D3 + Vitamin E (D-Alpha Tocopheryl Acetate))
drugbank:brandMixture Liquid Vitamin a-D-E-25t (Vitamin a Propionate + Vitamin D3 + Vitamin E (D-Alpha Tocopheryl Acetate))
drugbank:brandMixture Luna Vitamin and Mineral Bar for Women (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Phosphate (Dibasic)) + Chromium (Chromium Hvp Chelate) + D-Pantothenic Acid + Folic Acid + Iodine (Pota
drugbank:brandMixture Maintain Multiple Vitamin & Minerals (Biotin + Calcium (Calcium Hvp Chelate) + Choline Bitartrate + Chromium (Chromium Hvp Chelate) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid + Dl-Methionine +
drugbank:brandMixture Men's Biomultiple Vitamin and Mineral Supplement (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Carbonate) + Choline Bitartrate + Chromium (Yeast) + Copper (Copper Hvp Chelate) + D-Pantothe
drugbank:brandMixture Multi Vitamin - Mineral (Beta-Carotene (Provitamin a) + Biotin + Chromium (Chromium Hvp Chelate) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Pota
drugbank:brandMixture Multi Vitamin with Extra B's & Minerals (Biotin + Calcium (Calcium Phosphate, Calcium Carbonate) + Choline Bitartrate + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Dl-Met
drugbank:brandMixture Multi Vitamin-Mineral Formula (Calcium (Calcium Gluconate) + Choline Bitartrate + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Inositol + Iodine (Potassium Io
drugbank:brandMixture Multi-Vitamin Dietary Supplement (Beta-Carotene (Provitamin a) + D-Pantothenic Acid + Folic Acid + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vi
drugbank:brandMixture Mycelized Childrens Multi-Vitamin Liq (Biotin + D-Alpha Tocopherol + Dexpanthenol + Folic Acid + Nicotinic Acid + Vitamin a Palmitate + Vitamin B1 + Vitamin B12 + Vitamin B2 + Vitamin B6 + Vitamin C +
drugbank:brandMixture Natural Source Vitamin a & D Dietary Supplement (Vitamin a (Fish Liver Oil) + Vitamin D (Fish Liver Oil))
drugbank:brandMixture Natural Source Vitamin a and D Cap (Vitamin a (Fish Liver Oil) + Vitamin D3 (Fish Liver Oil))
drugbank:brandMixture Nutribuddies Vitamin Supplement (Vitamin a (Beta-Carotene) + Vitamin C + Vitamin E (D-Alpha Tocopherol))
drugbank:brandMixture One Daily Vitamin and Mineral Dietary Supplement (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Phosphate (Dibasic)) + Chlorine (Potassium Chloride) + Chromium (Chromium Hvp Chelate) + Copp
drugbank:brandMixture Optivite Vitamin and Mineral Supplement Tablet (Beta-Carotene + Copper (Cupric Oxide) + Selenium (Sodium Selenate) + Vitamin C + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide))
drugbank:brandMixture Original Bioscal Forte Multi-Vitamin Supplement Capsules (Beta-Carotene (Provitamin a) + Biotin + D-Pantothenic Acid (Calcium D-Pantothenate) + Vitamin B1 + Vitamin B2 + Vitamin B6 + Vitamin C + Vitam
drugbank:brandMixture Oxytene Vitamin a,C,E with Selenium Tab (Beta-Carotene + D-Alpha Tocopheryl Acid Succinate + Selenium + Vitamin a + Vitamin C)
drugbank:brandMixture Oxytetracycline Vitamin Beef Crumbles (Oxytetracycline Hydrochloride + Vitamin a + Vitamin D3 + Vitamin E)
drugbank:brandMixture Prenatal Vitamin and Mineral Supplement -Tab (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Carbonate) + Chromium (Chromic Chloride) + Copper (Cupric Oxide) + D-Pantothenic Acid (Calcium D-
drugbank:brandMixture Spectra 301 Vitamin and Mineral Supp (D-Pantothenic Acid (Calcium D-Pantothenate) + Magnesium (Magnesium Hvp Chelate) + Potassium (Potassium Gluconate) + Vitamin C (Vitamin C) + Zinc (Zinc Gluconate))
drugbank:brandMixture Super-Pote Vitamin Supplement (Biotin + Choline Bitartrate + D-Pantothenic Acid + Inositol + Nicotinamide + Vitamin a (Vitamin a Acetate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Cyanocoba
drugbank:brandMixture Vitamin & Mineral Formula 1 Dietary Supplement (Calcium (Calcium Phosphate (Dibasic)) + Choline Bitartrate + Copper (Copper Gluconate) + D-Pantothenic Acid + Folic Acid + Inositol + Iodine (Kelp) + Ir
drugbank:brandMixture Vitamin Ad Cap (Vitamin a + Vitamin D)
drugbank:brandMixture Vitamin C and a -Tab (Vitamin a Acetate + Vitamin C)
drugbank:brandMixture Vitamin a C E W.Niacinam.Beta Car.And Min. (Beta-Carotene + Copper (Copper Gluconate) + D-Alpha Tocopheryl Acetate + Nicotinamide + Selenium (Yeast) + Vitamin a Palmitate + Vitamin C (Calcium Ascorbat
drugbank:brandMixture Vitamin a D Inj (Vitamin a + Vitamin D)
drugbank:brandMixture Vitamin a and D Cap (Vitamin a + Vitamin D)
drugbank:brandMixture Vitamin a&D Tab (Vitamin a + Vitamin D)
drugbank:brandMixture Vitamin a-D Injectable (Vitamin a + Vitamin D3)
drugbank:brandMixture Vitamin and Mineral Formula (Biotin + Calcium (Calcium Carbonate) + Calcium D-Pantothenate + Inositol + Pyridoxine Hydrochloride + Vitamin B2 + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Sul
drugbank:brandMixture Vitamin and Mineral Supplement Capsules (Copper (Cupric Oxide) + Vitamin C (Ascorbic Acid) + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide))
drugbank:brandMixture Women's Biomultiple Vitamin and Mineral Supplement (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Carbonate) + Choline Bitartrate + Chromium (Yeast) + Copper (Copper Hvp Chelate) + D-Pantot
drugbank:brandMixture Z-Mass Pm Vitamin and Mineral Supplement (Magnesium (Magnesium Hvp Chelate) + Potassium (Potassium Citrate) + Vitamin B6 (Pyridoxine Hydrochloride) + Zinc (Zinc Hvp Chelate))
drugbank:brandName A-Mulsal
drugbank:brandName A-Sol
drugbank:brandName A-Vi-Pel
drugbank:brandName A-Vitan
drugbank:brandName Acon
drugbank:brandName Afaxin
drugbank:brandName Agiolan
drugbank:brandName Agoncal
drugbank:brandName Alcovit A
drugbank:brandName Alphalin
drugbank:brandName Alphasterol
drugbank:brandName Anatola
drugbank:brandName Anatola A
drugbank:brandName Anti-Infective vitamin
drugbank:brandName Antixerophthalmic vitamin
drugbank:brandName Aoral
drugbank:brandName Apexol
drugbank:brandName Apostavit
drugbank:brandName Aquasol A
drugbank:brandName Aquasol A Parenteral
drugbank:brandName Aquasynth
drugbank:brandName Atars
drugbank:brandName Atav
drugbank:brandName Avibon
drugbank:brandName Avita
drugbank:brandName Avitol
drugbank:brandName Axerol
drugbank:brandName Axerophthol
drugbank:brandName Bentavit A
drugbank:brandName Biosterol
drugbank:brandName Chocola A
drugbank:brandName Cylasphere
drugbank:brandName Del-VI-A
drugbank:brandName Disatabs Tabs
drugbank:brandName Dofsol
drugbank:brandName Dohyfral A
drugbank:brandName Epiteliol
drugbank:brandName Hi-A-Vita
drugbank:brandName Homagenets Aoral
drugbank:brandName Homagenets aorl
drugbank:brandName Lard Factor
drugbank:brandName M.V.C. 9+3
drugbank:brandName M.V.I. Pediatric
drugbank:brandName M.V.I.-12
drugbank:brandName Mvc Plus
drugbank:brandName Myvpack
drugbank:brandName Nio-A-Let
drugbank:brandName Oleovitamin A
drugbank:brandName Ophthalamin
drugbank:brandName Plivit A
drugbank:casRegistryNumber <http://bio2rdf.org/cas:68-26-8>
drugbank:chebiId <http://bio2rdf.org/chebi:17336>
drugbank:chemicalFormula C20H30O
drugbank:chemicalIupacName 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraen-1-ol
drugbank:contraindicationInsert <http://129.128.185.122/drugbank2/drugs/DB00162/inserts/1663/full>
drugbank:creationDate 2005-06-13 13:24:05 UTC
drugbank:description Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. [PubChem]
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/capsuleOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/emulsionOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/solution/DropsOral>
drugbank:dosageForm <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/dosageforms/tabletOral>
drugbank:dpdDrugIdNumber 00518565
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/anti-acneAgents>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/essentialVitamin>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/vitamins>
drugbank:drugCategory <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugcategory/vitamins(vitaminA)>
drugbank:drugIdNumberPage <http://205.193.93.51/dpdonline/searchRequest.do?din=00518565>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/approved>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/nutraceutical>
drugbank:drugType <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/drugtype/smallMolecule>
drugbank:experimentalLogpHydrophobicity 4.1
drugbank:experimentalWaterSolubility 0.671 mg/L
drugbank:genericName Vitamin A
drugbank:halfLife 1.9 hours
drugbank:inchiIdentifier InChI=1/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
drugbank:inchiKey FPIPGXGPPPQFEQ-UHFFFAOYAF
drugbank:indication For the treatment of vitamin A deficiency.
drugbank:interactionInsert <http://129.128.185.122/drugbank2/drugs/DB00162/inserts/2643/full>
drugbank:keggCompoundId <http://bio2rdf.org/cpd:C00473>
drugbank:keggDrugId <http://bio2rdf.org/kegg:D00069>
rdfs:label Vitamin A
drugbank:limsDrugId 162
drugbank:massSpecFile 1
drugbank:mechanismOfAction Vision:Vitamin A (all-<i>trans</i> retinol) is converted in the retina to the 11-<i>cis</i>-isomer of retinaldehyde or 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-<i>cis</i>-retinal, while attached to opsin in rhodopsin is isomerized to all-<i>trans</i>-retinal by light. This is the event that triggers the nerve impulse to the brain which allows for the perception of light. All-<i>trans</i>-retinal is then released from opsin and reduced to all-<i>trans</i>-retinol. All-<i>trans</i>-retinol is isomerized to 11-<i>cis</i>-retinol in the dark, and then oxidized to 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal recombines with opsin to re-form rhodopsin. Night blindness or defective vision at low illumination results from a failure to re-synthesize 11-<i>cis</i> retinal rapidly. <br/>Epithelial differentiation: The role of Vitamin A in epithelial differentiation, as well as in other physiological processes, involves the binding of Vitamin A to two families of nuclear retinoid receptors (retinoic acid receptors, RARs; and retinoid-X receptors, RXRs). These receptors function as ligand-activated transcription factors that modulate gene transcription. When there is not enough Vitamin A to bind these receptors, natural cell differentiation and growth are interrupted.
drugbank:meltingPoint 63.5 oC, 57 oC (Vitamin A acetate), 28-30 oC (Vitamin A palmitate)
drugbank:molecularWeightAverage 286.4516
drugbank:molecularWeightMono 286.2297
drugbank:msdsFiles /drugs/162/safety_sheets/1271
foaf:page <http://dbpedia.org/page/Vitamin_A>
foaf:page <http://en.wikipedia.org/wiki/Vitamin_A>
foaf:page <http://www.drugbank.ca/drugs/DB00162>
drugbank:patientInformationInsert http://129.128.185.122/drugbank2/drugs/DB00162/inserts/663/full
drugbank:pdbExperimentalId 1JYD
drugbank:pdrhealthLink http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0260.shtml
drugbank:pharmacology Vitamin A is effective for the treatment of Vitamin A deficiency. Vitamin A refers to a group of fat-soluble substances that are structurally related to and possess the biological activity of the parent substance of the group called all-<i>trans</i> retinol or retinol. Vitamin A plays vital roles in vision, epithelial differentiation, growth, reproduction, pattern formation during embryogenesis, bone development, hematopoiesis and brain development. It is also important for the maintenance of the proper functioning of the immune system.
drugbank:pharmgkbId PA451884
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/1652>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/169>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/2418>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/2419>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/2880>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3372>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3739>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3758>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3776>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/3778>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/427>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/662>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/837>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/991>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/992>
drugbank:possibleDiseaseTarget <http://wifo5-04.informatik.uni-mannheim.de/diseasome/resource/diseases/994>
drugbank:predictedLogpHydrophobicity 6.38
drugbank:predictedLogs -4.58
drugbank:predictedWaterSolubility 7.58e-03 mg/mL
drugbank:primaryAccessionNo DB00162
drugbank:proteinBinding <5% of circulating vitamin A is bound to lipoproteins in blood in normal condition, but may be up to 65% when hepatic stores are saturated because of excessive intake. When released from liver, vitamin A is bound to retinol-binding protein (RBP). Most vitamin A circulates in the form of retinol bound to RBP.
drugbank:pubchemCompoundId 1071
drugbank:pubchemSubstanceId 3756
drugbank:reference
drugbank:rxlistLink <http://www.rxlist.com/cgi/generic2/aquasola.htm>
owl:sameAs <http://data.linkedct.org/resource/intervention/15179>
owl:sameAs <http://data.linkedct.org/resource/intervention/23339>
owl:sameAs <http://data.linkedct.org/resource/intervention/24196>
owl:sameAs <http://data.linkedct.org/resource/intervention/53508>
owl:sameAs <http://data.linkedct.org/resource/intervention/55972>
owl:sameAs <http://dbpedia.org/resource/Vitamin_A>
owl:sameAs <http://wifo5-04.informatik.uni-mannheim.de/sider/resource/drugs/1071>
drugbank:secondaryAccessionNumber aprd00486
drugbank:secondaryAccessionNumber nutr00007
drugbank:smilesStringCanonical CC(C=CC=C(C)C=CC1=C(C)CCCC1(C)C)=CCO
drugbank:smilesStringIsomeric CC(C=CC=C(C)C=CC1=C(C)CCCC1(C)C)=C/CO
drugbank:state Solid
drugbank:structure 1
drugbank:synonym All-trans-Retinyl alcohol
drugbank:synonym All-trans-Vitamin A alcohol
drugbank:synonym Retin-11,12-t2-ol (9CI)
drugbank:synonym Retinol
drugbank:synonym Vitamin A (Feed)
drugbank:synonym Vitamin A Palmitate
drugbank:synonym Vitamin A Solubilized
drugbank:synonym Vitamin A alcohol
drugbank:synonym Vitamin A cryst
drugbank:synonym Vitamin A1
drugbank:synonym Vitamin A1 alcohol
drugbank:synonym [11,12-3H]-Retinol
drugbank:synonym all-trans-Vitamin A
drugbank:synonym all-trans-Vitamin A1
drugbank:synonym all-trans-retinol
drugbank:synonym beta-Retinol
drugbank:synonym trans-Retinol
drugbank:synonym trans-Vitamin A alcohol
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/1097>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/282>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/331>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/345>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/35>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/4071>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/4072>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/4073>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/4074>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/4075>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/561>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/569>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/589>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/611>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/627>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/640>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/651>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/753>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/800>
drugbank:target <http://wifo5-04.informatik.uni-mannheim.de/drugbank/resource/targets/863>
drugbank:toxicity Acute toxicity (single ingestion of 7 500 RE or 25 000 IU per kg or more): Signs and symptoms may be delayed for 8 to 24 hours and include: increased intracranial pressure, headache, irritability, drowsiness, dizziness, lethargy, vomiting, diarrhea, bulging of fontanels in infants, diplopia, papilledema. Peeling of skin around mouth may be observed from 1 to several days after ingestion and may spread to the rest of the body. Chronic, excessive ingestion (1 200 RE or 4 000 IU/kg daily for 6 to 15 months) may produce symptoms of pseudotumor cerebri, anorexia, weakness, arthralgias, bone pain, bone demineralization, dry skin, cracked lips, brittle nails, hair loss, splenomegaly, hepatomegaly, hypoplastic anemia, leukopenia, optic neuropathy, and blindness. Increased plasma concentrations of vitamin A occur but do not necessarily correlate with toxicity.
rdf:type drugbank:drugs
rdf:type vocabClass:Offer
drugbank:updateDate 2008-08-26 15:30:10 UTC

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